In this prospective, multicentre, international, randomised, parallel, double-masked, placebo-controlled trial, women with type 2 diabetes during pregnancy were randomly assigned from 25 centres in Canada and four in Australia to receive either metformin 1000 mg twice daily or placebo, added to insulin. The study found several maternal glycaemic and neonatal adiposity benefits in the metformin group. Along with reduced maternal weight gain and insulin dosage and improved glycaemic control, the lower adiposity and infant size measurements resulted in fewer large infants but a higher proportion of small-for-gestational-age infants. Understanding the implications of these effects on infants will be important to properly advise patients who are contemplating the use of metformin during pregnancy.

https://www.thelancet.com/journals/landia/article/PIIS2213-8587(20)30310-7/fulltext?utm_source=MHTF+Subscribers&utm_campaign=a8914a6961-EMAIL_CAMPAIGN_2018_07_27_03_30_COPY_01&utm_medium=email&utm_term=0_8ac9c53ad4-a8914a6961-183804741

References

  1. Feig DS Hwee J Shah BR Booth GL Bierman AS Lipscombe LL. Trends in incidence of diabetes in pregnancy and serious perinatal outcomes: a large, population-based study in Ontario, Canada, 1996–2010. Diabetes Care. 2014; 37: 1590-1596

  2. Lascar N Brown J Pattison H Barnett AH Bailey CJ Bellary S. Type 2 diabetes in adolescents and young adults. Lancet Diabetes Endocrinol. 2018; 6: 69-80

  3. Santos S Voerman E Amiano P et al. Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts. BJOG. 2019; 126: 984-995

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Maternal Health  Maternal/Fetal health during pregnancy  

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