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Through funding provided by the UCT Collaborating Centre for Optimising Antimalarial Therapy (CCOAT) Global Research Nurses (GRN) was introduced to over 50 nurses in this rural province of South Africa, situated on the Momambique and Swaziland borders. Nurses attended one of several talks given by Dr Elize Pietersen, GRN coordinator. Some attendees were involved in CCOAT antimalarial clinical trials while others had no previous exposure to clinical research. Most were excited to learn about the support and resources available via GRN and expressed a need for seminars/workshops (for themselves and/or their students) that address the research process in actual terms (i.e. while conducting their own research). However there are specific challenges for accessing resources through the web in this low income context due to a lack of computers and/or internet at home, limited computer literacy and no time/limited time at work to engage with online learning/resources. These are not easy issues to solve, though GRN will continue to explore possible ways forward, such as a blended-learning approach piloted by Global Health Network regional faculties. Specific questions from this audience included a) How does one become a clinical research nurse? The lecturer who raised this question would like to move into a clinical research nursing career after her PhD and b) Where does one get funding to do clinical research? These questions reflect common themes observed during Elize’s recent engagements with nurses, and for which resources will be made available through GRN.